Description
| Summary: | This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
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| Item Description: | "Doctoral thesis accepted by University of Science and Technology of China, Hefei, China." |
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| Physical Description: | 1 online resource (xv, 156 pages) : illustrations (chiefly color). |
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| ISBN: | 9789811681660
981168166X |
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| ISSN: | 2190-5061 |
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| Source of Description, Etc. Note: | Online resource; title from PDF title page (SpringerLink, viewed January 10, 2022). |
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