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00000cam a2200000 i 4500 |
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on1291610951 |
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OCoLC |
| 005 |
20240623213015.0 |
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m o d |
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cr cnu|||unuuu |
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220111s2022 si a o 000 0 eng d |
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|a GW5XE
|b eng
|e rda
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|c GW5XE
|d YDX
|d EBLCP
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|d OCLCF
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|a 1291635031
|a 1291693208
|a 1291732590
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|a 1294363971
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|a 9789811681660
|q (electronic bk.)
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|a 981168166X
|q (electronic bk.)
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|z 9789811681653
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|z 9811681651
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| 024 |
7 |
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|a 10.1007/978-981-16-8166-0
|2 doi
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| 035 |
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|a (OCoLC)1291610951
|z (OCoLC)1291635031
|z (OCoLC)1291693208
|z (OCoLC)1291732590
|z (OCoLC)1291878453
|z (OCoLC)1294363971
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|b Springer
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|a TA418.9.N35
|b Z53 2022
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|a TBN
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|a TEC027000
|2 bisacsh
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|a TBN
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|a HCDD
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| 100 |
1 |
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|a Zhang, Yunjiao,
|e author.
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| 245 |
1 |
0 |
|a Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals /
|c Yunjiao Zhang.
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| 264 |
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1 |
|a Singapore :
|b Springer,
|c [2022]
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| 264 |
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4 |
|c ©2022
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| 300 |
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|a 1 online resource (xv, 156 pages) :
|b illustrations (chiefly color).
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a text file
|b PDF
|2 rda
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| 490 |
1 |
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|a Springer theses,
|x 2190-5061
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| 500 |
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|a "Doctoral thesis accepted by University of Science and Technology of China, Hefei, China."
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| 520 |
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|a This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
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| 505 |
0 |
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|a Introduction -- Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials -- RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN) -- Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating -- RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo -- Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.
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| 588 |
0 |
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|a Online resource; title from PDF title page (SpringerLink, viewed January 10, 2022).
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| 650 |
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|a Nanocrystals.
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| 650 |
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|a Rare earths.
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| 650 |
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|a Cell death.
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| 650 |
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7 |
|a Cell death
|2 fast
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| 650 |
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7 |
|a Nanocrystals
|2 fast
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| 650 |
|
7 |
|a Rare earths
|2 fast
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| 758 |
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|i has work:
|a TUNING AUTOPHAGYDUCING ACTIVITY AND TOXICITY FOR LANTHANIDE NANOCRYSTALS (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCYkHpjG4YWqp6hKdqb8dXq
|4 https://id.oclc.org/worldcat/ontology/hasWork
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| 776 |
0 |
8 |
|c Original
|z 9811681651
|z 9789811681653
|w (OCoLC)1280391263
|
| 830 |
|
0 |
|a Springer theses.
|x 2190-5061
|
| 856 |
4 |
0 |
|u https://holycross.idm.oclc.org/login?auth=cas&url=https://link.springer.com/10.1007/978-981-16-8166-0
|y Click for online access
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| 903 |
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|a SPRING-CHEM2020
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| 994 |
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|a 92
|b HCD
|