Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals

Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals / Yunjiao Zhang.

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN...

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Bibliographic Details
Main Author: Zhang, Yunjiao (Author)
Format: eBook
Language:English
Published: Singapore : Springer, [2022]
Series:Springer theses.
Subjects:
Nanocrystals.
Rare earths.
Cell death.
Cell death
Nanocrystals
Rare earths
Online Access:Click for online access
Table of Contents:
  • Introduction
  • Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials
  • RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN)
  • Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating
  • RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo
  • Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.

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