High altitude sickness -- solutions from genomics, proteomics and antioxidant interventions

High altitude sickness -- solutions from genomics, proteomics and antioxidant interventions / Narendra Kumar Sharma, Aditya Arya, editors.

This book reviews the recent advances in the development of proteomics-based biomarkers for the non-invasive diagnosis of altitude sickness and explores the potential of antioxidant therapy for this sickness. The first chapters introduce the associated pathophysiology and provide mechanistic insight...

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Bibliographic Details
Other Authors: Sharma, Narendra Kumar, Arya, Aditya
Format: eBook
Language:English
Published: Singapore : Springer, 2022.
Subjects:
Mountain sickness.
Anoxemia.
Anoxemia
Mountain sickness
Anoxèmia.
Llibres electrònics.
Online Access:Click for online access
Table of Contents:
  • Intro
  • Preface
  • About the Book
  • Contents
  • About the Editors
  • 1: Introduction to High Altitude and Hypoxia
  • 1.1 Introduction
  • 1.2 High Altitude and Oxygen Availability
  • 1.3 Acclimatization at High Altitude
  • 1.3.1 Acute Mountain Sickness
  • 1.3.2 High Altitude Cerebral Oedema (HACE)
  • 1.3.2.1 Intracellular Oedema
  • 1.3.2.2 Ionic Oedema
  • 1.3.2.3 Vasogenic Oedema
  • 1.3.3 High Altitude Pulmonary Oedema (HAPE)
  • 1.4 Hypobaric Hypoxia and Brain
  • 1.4.1 Brain as a Vulnerable Site of Oxidative Stress
  • 1.4.2 Hypobaric Hypoxia and Memory Functions
  • 1.5 Other Neurological Effects at High Altitude
  • References
  • 2: High Altitude Sickness: Environmental Stressor and Altered Physiological Response
  • 2.1 Introduction
  • 2.1.1 High Altitudes
  • 2.1.2 Environment at High Altitudes and Defining ``Hypoxia ́́
  • 2.1.2.1 Identifying the Concept of ``Hypoxia ́́
  • 2.1.2.2 Types of Hypoxia
  • 2.1.2.3 Symptoms of High Altitude Hypoxia
  • 2.1.3 Ultraviolet Radiation
  • 2.1.4 Cold
  • 2.2 Physiological Changes at High Altitude
  • 2.2.1 Acclimatization to High Altitude
  • 2.2.1.1 Pulmonary Ventilation or Hyperventilation
  • 2.2.1.2 Polycythaemia
  • 2.2.2 Affinity of Haemoglobin for Oxygen at Sea Level and At High Altitudes
  • 2.2.3 High Altitude and Oxidative Stress
  • 2.3 Conclusion
  • References
  • 3: High Altitude Related Diseases: Milder Effects, HACE, HAPE, and Effect on Various Organ Systems
  • 3.1 Introduction
  • 3.2 Epidemiology of High Altitude Sickness
  • 3.3 Mechanisms of High Altitude Sickness
  • 3.4 Milder Effects of High Altitude (AMS)
  • 3.5 High Altitude Pulmonary Oedema (HAPE)
  • 3.6 High Altitude Cerebral Oedema (HACE)
  • 3.7 High Altitude Related Cardiac Perturbations
  • 3.8 High Altitude Related Perturbations in Muscles
  • 3.9 High Altitude Related Perturbations in Kidney
  • 3.10 High Altitude Related Perturbations in Liver
  • 3.11 Conclusion
  • References
  • 4: High Altitude-Induced Oxidative Stress, Rheumatoid Arthritis, and Proteomic Alteration
  • 4.1 Oxidative Stress
  • 4.1.1 Oxidants
  • 4.1.1.1 Endogenous Source
  • 4.1.1.2 Exogenous Source
  • 4.1.2 Antioxidants
  • 4.2 High Altitude Mediated Oxidative Stress
  • 4.2.1 High Altitude and Oxidative Damage
  • 4.2.2 RONS Generation at High Altitude
  • 4.2.3 Hypoxia and Oxidative Stress
  • 4.3 Rheumatoid Arthritis (RA)
  • 4.3.1 Oxidative Stress in RA
  • 4.3.2 High Altitude and RA
  • 4.3.3 Reactive Species Measurement in RA
  • 4.4 Oxidative Stress Measurement
  • 4.5 High Altitude and Proteomic Alteration
  • 4.6 Conclusion
  • References
  • 5: Oxidative Stress, ROS Generation, and Associated Molecular Alterations in High Altitude Hypoxia
  • 5.1 Introduction
  • 5.2 Mechanisms of Oxidant Generation
  • 5.2.1 Oxidants Generation in Mitochondria
  • 5.2.2 Oxidant Generation in Phagocytic and Non-phagocytic Cells
  • 5.3 Defence Mechanism Against Oxidative Stress
  • 5.3.1 Enzymatic Antioxidants
  • 5.3.2 Non-Enzymatic Antioxidants

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