PI3K and AKT isoforms in immunity : mechanisms and therapeutic opportunities

PI3K and AKT isoforms in immunity : mechanisms and therapeutic opportunities / Margarita Dominguez-Villar, editor.

This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell d...

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Bibliographic Details
Other Authors: Dominguez-Villar, Margarita (Editor)
Format: eBook
Language:English
Published: Cham : Springer, 2022.
Series:Current topics in microbiology and immunology ; 436.
Subjects:
Molecular immunology.
Phosphoinositides.
Molecular immunology
Phosphoinositides
Fosfatidilinositols.
Immunitat cel·lular.
Llibres electrònics.
Online Access:Click for online access
Table of Contents:
  • Class I PI3K biology
  • Class II PI3K biology
  • Class III PI3K biology
  • PTEN in immunity
  • PHLPP Signaling in Immune Cells
  • PHLPP Signaling in Immune Cells
  • PI3K isoforms in cell signalling and innate immune cell responses
  • AKT isoforms in macrophage activation, polarization and survival
  • Control of CD4+ T cell Differentiation and Function by PI3K isoforms.
  • PI3K isoforms in CD8+ T cell development and function
  • PI3K isoforms in B cells
  • PI3K isoform signalling in platelets
  • PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection
  • PI3K and AKT at the Interface of Signaling and Metabolism
  • The Role of PI3K Isoforms in Autoimmune Disease
  • AKT Isoforms in the Immune Response in Cancer
  • PI3K isoform immunotherapy for solid tumours
  • PI3K targeting in non-solid cancer
  • AKT isoforms as a target in cancer and immunotherapy
  • Developing PI3K Inhibitors for Respiratory Diseases.

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