Voltage-gated calcium channels

Voltage-gated calcium channels / Gerald Werner Zamponi, Norbert Weiss, editors.

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical informat...

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Bibliographic Details
Other Authors: Zamponi, Gerald W. (Editor), Weiss, Norbert, 1978- (Editor)
Format: eBook
Language:English
Published: Cham : Springer, [2022]
Edition:[2022 edition].
Series:Molecular Biology Intelligence Unit
Subjects:
Calcium channels.
Calcium channels
Online Access:Click for online access
Table of Contents:
  • Intro
  • Preface
  • Contents
  • A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century
  • Ca2+ as Central Ion for Muscle Contraction
  • The "Ca-Spikes" of Crustacean Skeletal Muscles
  • "Ca-Spikes" in Heart and Neurons
  • How to Look at Ca2+ Currents Through Voltage-Clamp Recordings
  • Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents
  • A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells
  • The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels
  • The Discovery of the "Low-Voltage Activated" T-Type Channel
  • The Unique Properties of T-Type (LVA) Channels
  • The Explosive Interest on T-Type Channels
  • The Ca2+ Channel Family Growths
  • The N-Type Channel
  • The P/Q-Type Channel
  • The R-Type Channel
  • From Ionic Currents to the Molecular Structure of Ca2+ Channels
  • The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ Channel Modulation
  • Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels
  • Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels
  • Looking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins
  • Take-Home Message
  • References
  • Part I: Structural and Molecular Aspects of VGCCs
  • Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels
  • Introduction
  • Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels
  • Structures of NaVAb and CaVAb Channels
  • Structure of the Skeletal Muscle CaV1.1 Calcium Channel
  • Molecular Properties of the CaV2 Family of Calcium Channels
  • Structure of CaV2.2 Calcium Channels and Implications for Regulation
  • Molecular Properties and Structure of CaV3 Calcium Channels
  • Pharmacology of Calcium Channels
  • Conclusion
  • References
  • Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels
  • Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing
  • Splice Variations in High Voltage-Activated Calcium Channels
  • CaV1.1 Splice Variant in Myotonic Dystrophy
  • CaV1.2 Splice Variants in Health and Disease
  • Exon 9* in Cardiovascular Diseases
  • Mutually Exclusive Exons 1a/1 and Exons 8a/8
  • Exons 21/22
  • Exon 33 and Exon 33L

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