Extracellular vesicles in cardiovascular and metabolic diseases

Extracellular vesicles in cardiovascular and metabolic diseases / Junjie Xiao, editor.

This book provides the latest research progress on Extracellular vesicles (EVs) in cardiovascular and metabolic diseases. EVs are small bilayer lipid membrane vesicles released by cells and function for intercellular communication. Increasing evidence has shown that EVs play crucial roles in cardiov...

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Bibliographic Details
Other Authors: Xiao, Junjie, 1983- (Editor)
Format: eBook
Language:English
Published: Singapore : Springer, [2023]
Series:Advances in experimental medicine and biology ; v. 1418.
Subjects:
Cardiovascular system > Diseases.
Metabolism > Disorders.
Extracellular space.
Cell organelles.
Cytology.
Cardiovascular system > Diseases
Cell organelles
Cytology
Extracellular space
Metabolism > Disorders
Online Access:Click for online access
Table of Contents:
  • Intro
  • Preface
  • Contents
  • Part I: Extraction Methods
  • 1: Updated Methods of Extracellular Vesicles Isolation
  • 1.1 Background
  • 1.2 The Regular Methods of EVs Isolation
  • 1.2.1 Ultracentrifugation (UC)
  • 1.2.2 Density Gradient Centrifugation (DGC)
  • 1.2.3 Size-Exclusion Chromatography (SEC)
  • 1.2.4 Ultrafiltration (UF)
  • 1.2.5 Immunoaffinity Capture (IAC)
  • 1.2.6 Precipitation
  • 1.3 Novel Method of EVs Extraction
  • 1.3.1 Microfluidics-Based EVs Isolation Technique
  • 1.3.2 Creative Combination of Different Methods
  • 1.3.3 Newly Emerging Methods for EVs Isolation
  • 1.4 Recommended Methods for EVs Isolation from Biofluids
  • 1.4.1 Plasma or Serum
  • 1.4.2 Urine
  • 1.4.3 Milk
  • 1.4.4 Saliva
  • 1.5 Recommended Protocols for EVs Extraction from Tissues
  • 1.5.1 Brain
  • 1.5.2 Intestinal Tissue
  • 1.5.3 Muscles
  • 1.5.4 Heart
  • 1.6 Perspective
  • References
  • Part II: Extracellular Vesicles in Cardiovascular Disease
  • 2: Extracellular Vesicles and Pathological Cardiac Hypertrophy
  • 2.1 Background
  • 2.2 Cardiomyocyte-Derived EVs on Pathological Cardiac Hypertrophy
  • 2.3 Cardiac Fibroblast-Derived EVs on Pathological Cardiac Hypertrophy
  • 2.4 EVs from Other Cell Types in Pathological Cardiac Hypertrophy
  • 2.5 Stem Cell-Derived Exosomes on Pathological Cardiac Hypertrophy
  • 2.6 Exosomes from Cardiosphere-Derived Cells on Pathological Cardiac Hypertrophy
  • 2.7 Translational Perspective
  • 2.8 Conclusion
  • References
  • 3: Extracellular Vesicles and Cardiac Aging
  • 3.1 Background
  • 3.2 Accumulation of Cellular Injury and Cell Senescence
  • 3.2.1 EVs, Aging, and Cell Senescence
  • 3.3 Cardiac Aging and Cell Senescence
  • 3.3.1 Cardiomyocytes
  • 3.3.2 Fibroblasts
  • 3.3.3 Endothelial Cells
  • 3.3.4 Stem and Progenitor Cells
  • 3.4 Promising Approaches: Mitochondria-Enriched Vesicles
  • 3.5 Perspectives
  • References
  • 4: Extracellular Vesicles and Ischemic Cardiovascular Diseases
  • 4.1 Background
  • 4.2 Different Sources of Extracellular Vesicles for Therapy of Ischemic Cardiovascular Diseases
  • 4.3 Native Extracellular Vesicles for Ischemic Cardiovascular Therapeutics
  • 4.4 Bioengineered Extracellular Vesicles for Ischemic Cardiovascular Therapeutics
  • 4.5 EVs as Potential Biomarkers of Ischemic Cardiovascular Diseases
  • 4.6 Conclusion and Future Perspectives
  • References
  • 5: Extracellular Vesicles and Hypertension
  • 5.1 Background
  • 5.2 Extracellular Vesicles and Essential Hypertension
  • 5.2.1 Roles of Extracellular Vesicles in Renin-Angiotensin-Aldosterone System
  • 5.2.2 Roles of Extracellular Vesicles in Vascular Endothelial Cells
  • 5.2.3 Roles of Extracellular Vesicles in Vascular Smooth Muscle Cells
  • 5.2.4 Roles of Extracellular Vesicles in Vascular Fibroblasts
  • 5.3 Extracellular Vesicles and Secondary Hypertension
  • 5.3.1 Extracellular Vesicles and Acute Kidney Injury
  • 5.3.2 Extracellular Vesicles and Renal Parenchymal Diseases

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