Sex and gender differences in infection and treatments for infectious diseases

Sex and gender differences in infection and treatments for infectious diseases / Sabra L. Klein, Craig W. Roberts, editors.

This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how r...

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Bibliographic Details
Other Authors: Klein, Sabra L., Roberts, Craig W.
Format: eBook
Language:English
Published: Cham : Springer, 2023.
Edition:2nd ed.
Series:Current topics in microbiology and immunology ; v. 441.
Subjects:
Communicable diseases > Sex factors.
Communicable diseases > Treatment > Sex factors.
Sex factors in disease.
Online Access:Click for online access
Table of Contents:
  • Intro
  • Contents
  • Genetics of Sex Differences in Immunity
  • 1 Evolutionary Perspective
  • 2 Sex Chromosomes
  • 2.1 X Chromosome Inactivation
  • 2.2 Immune-Related Genes on the Sex Chromosomes
  • 2.3 Sex Chromosome Abnormalities and the Immune System
  • 3 Experimental Models for Studying the Sex Effect on Immunity
  • 3.1 Four Core Genotypes Mouse Model
  • 3.2 Human Cell Lines with Sex Chromosome Aberrations
  • 3.3 Additional Mouse Models
  • 4 Female-Specific States and Their Immune Consequences
  • 4.1 Pregnancy as a Graft
  • 4.2 Microchimerism in Fetal Cells
  • 5 Concluding Remarks
  • 4 Sex Differences in Allergic Asthma: A Prominent Role of Sex Steroid Hormone Signaling
  • 4.1 Sex Bias in Asthma Prevalence and Severity
  • 4.2 Impact of Sex Hormones in Type 2 Mediated Allergic Airway Inflammation
  • 5 Biological Sex Influences Natural Immunity to Neonatal Pathogens and Cancer
  • 5.1 Sex-Biased Dimorphism in Bloodstream Infections: The Role of Estrogens/Peritoneal Macrophages/B-1 Cells Axis
  • 5.2 Sex Dimorphism in Solid Tumor Control: From Innate to Acquired Immunity
  • References
  • Sex Differences in HIV Infection
  • 1 Introduction
  • 2 Sex Differences in HIV Acquisition
  • 3 Sex Differences in HIV Pathogenesis
  • 4 Immune Mechanisms Underlying Sex Differences
  • 5 Sex Differences in ART-Treated Disease
  • 6 Summary
  • References
  • Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes
  • 1 Sex Differences in Viral Pathogenesis
  • 2 Sex Differences in SARS-CoV-2 Pathogenesis
  • 2.1 SARS-CoV-2 Entry, Replication, and Transmission
  • 2.2 Development of Innate and Adaptive Immune Responses
  • 2.3 Sex Differences in Post-Acute Sequelae SARS-CoV-2 Infection (PASC)
  • 2.4 Comorbidities, Sex Difference, and COVID-19
  • 2.5 Role of Sex Steroids
  • 2.6 Role of Genetic Variations
  • 3 Pregnancy and SARS-CoV-2 Pathogenesis
  • 4 Sex Differences in COVID-19 Vaccine Outcomes
  • 4.1 Immunogenicity
  • 4.2 Effectiveness
  • 4.3 Vaccine Reactogenicity
  • 5 Pregnancy and COVID-19 Vaccines
  • 6 Conclusions and Future Directions
  • References
  • Biological Sex and Pregnancy Affect Influenza Pathogenesis and Vaccination
  • 1 Introduction
  • 2 Sex Differences in Influenza Pathogenesis
  • 2.1 Seasonal Influenza Epidemics
  • 2.2 Outbreaks of Avian Influenza
  • 2.3 Influenza A Virus Pandemics

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