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00000cam a22000007i 4500 |
| 001 |
on1399170835 |
| 003 |
OCoLC |
| 005 |
20240808213014.0 |
| 006 |
m o d |
| 007 |
cr cnu---unuuu |
| 008 |
230923s2023 sz o 000 0 eng d |
| 040 |
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|a EBLCP
|b eng
|c EBLCP
|d YDX
|d GW5XE
|d OCLCO
|d EBLCP
|d SFB
|d YDX
|d OCLCF
|d OCLCQ
|d OCLCO
|d UKAHL
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| 019 |
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|a 1398568578
|a 1402833087
|a 1406512379
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| 020 |
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|a 9783031358517
|q electronic book
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| 020 |
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|a 3031358511
|q electronic book
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| 020 |
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|z 3031358503
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| 020 |
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|z 9783031358500
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| 024 |
7 |
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|a 10.1007/978-3-031-35851-7
|2 doi
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| 035 |
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|a (OCoLC)1399170835
|z (OCoLC)1398568578
|z (OCoLC)1402833087
|z (OCoLC)1406512379
|
| 050 |
|
4 |
|a QH438.4.S73
|b S67 2023
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| 049 |
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|a HCDD
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| 100 |
1 |
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|a Sorensen, Daniel,
|e author.
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| 245 |
1 |
0 |
|a Statistical learning in genetics :
|b an introduction using R /
|c Daniel Sorensen.
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| 264 |
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1 |
|a Cham :
|b Springer International Publishing AG,
|c 2023.
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| 300 |
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|a 1 online resource (xvi, 693 pages).
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
|
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Statistics for Biology and Health Series
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| 520 |
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|a This book provides an introduction to computer-based methods for the analysis of genomic data. Breakthroughs in molecular and computational biology have contributed to the emergence of vast data sets, where millions of genetic markers for each individual are coupled with medical records, generating an unparalleled resource for linking human genetic variation to human biology and disease. Similar developments have taken place in animal and plant breeding, where genetic marker information is combined with production traits. An important task for the statistical geneticist is to adapt, construct and implement models that can extract information from these large-scale data. An initial step is to understand the methodology that underlies the probability models and to learn the modern computer-intensive methods required for fitting these models. The objective of this book, suitable for readers who wish to develop analytic skills to perform genomic research, is to provide guidance to take this first step. This book is addressed to numerate biologists who typically lack the formal mathematical background of the professional statistician. For this reason, considerably more detail in explanations and derivations is offered. It is written in a concise style and examples are used profusely. A large proportion of the examples involve programming with the open-source package R. The R code needed to solve the exercises is provided. The MarkDown interface allows the students to implement the code on their own computer, contributing to a better understanding of the underlying theory. Part I presents methods of inference based on likelihood and Bayesian methods, including computational techniques for fitting likelihood and Bayesian models. Part II discusses prediction for continuous and binary data using both frequentist and Bayesian approaches. Some of the models used for prediction are also used for gene discovery. The challenge is to find promising genes without incurring a large proportion of false positive results. Therefore, Part II includes a detour on False Discovery Rate assuming frequentist and Bayesian perspectives. The last chapter of Part II provides an overview of a selected number of non-parametric methods. Part III consists of exercises and their solutions. Daniel Sorensen holds PhD and DSc degrees from the University of Edinburgh and is an elected Fellow of the American Statistical Association. He was professor of Statistical Genetics at Aarhus University where, at present, he is professor emeritus.
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| 588 |
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|a Description based on online resource; title from digital title page (viewed on November 06, 2023).
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| 650 |
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0 |
|a Genetics
|x Statistical methods.
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| 650 |
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0 |
|a R (Computer program language)
|x Statistical methods.
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| 650 |
|
7 |
|a Genetics
|x Statistical methods
|2 fast
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| 650 |
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7 |
|a Genètica.
|2 thub
|
| 650 |
|
7 |
|a Estadística matemàtica.
|2 thub
|
| 650 |
|
7 |
|a R (Llenguatge de programació)
|2 thub
|
| 655 |
|
7 |
|a Llibres electrònics.
|2 thub
|
| 776 |
0 |
8 |
|i Print version:
|a Sorensen, Daniel
|t Statistical Learning in Genetics
|d Cham : Springer International Publishing AG,c2023
|z 9783031358500
|
| 830 |
|
0 |
|a Statistics for biology and health.
|
| 856 |
4 |
0 |
|u https://holycross.idm.oclc.org/login?auth=cas&url=https://link.springer.com/10.1007/978-3-031-35851-7
|y Click for online access
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| 903 |
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|a SPRING-ALL2023
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| 994 |
|
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|a 92
|b HCD
|