The Inflammasomes edited by Isabelle Couillin, Virginie Pétrilli, Fabio Martinon.
The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene,...
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